Ontology highlight
ABSTRACT:
ORGANISM(S): Drosophila melanogaster
SUBMITTER: Charles Girardot
PROVIDER: E-TABM-988 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Gutiérrez Luis L Oktaba Katarzyna K Scheuermann Johanna C JC Gambetta Maria Cristina MC Ly-Hartig Nga N Müller Jürg J
Development (Cambridge, England) 20111117 1
Polycomb group (PcG) proteins exist in multiprotein complexes that modify chromatin to repress transcription. Drosophila PcG proteins Sex combs extra (Sce; dRing) and Posterior sex combs (Psc) are core subunits of PRC1-type complexes. The Sce:Psc module acts as an E3 ligase for monoubiquitylation of histone H2A, an activity thought to be crucial for repression by PRC1-type complexes. Here, we created an Sce knockout allele and show that depletion of Sce results in loss of H2A monoubiquitylation ...[more]