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ChIP-chip of Drosophila Polycomb group proteins Pho and dSfmbt (PhoRC) in embryos and larvae

ABSTRACT: Analysis of binding profile of the Polycomb group proteins Pho and dSfmbt (PhoRC complex) in Drosophila melanogster at two developmental stages (embryos and larvae).

ORGANISM(S): Drosophila melanogaster

SUBMITTER: Charles Girardot

PROVIDER: E-TABM-525 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Dynamic regulation by polycomb group protein complexes controls pattern formation and the cell cycle in Drosophila.

Oktaba Katarzyna K Gutiérrez Luis L Gagneur Julien J Girardot Charles C Sengupta Aditya K AK Furlong Eileen E M EE Müller Jürg J

Developmental cell 20081106 6

Polycomb group (PcG) proteins form conserved regulatory complexes that modify chromatin to repress transcription. Here, we report genome-wide binding profiles of PhoRC, the Drosophila PcG protein complex containing the DNA-binding factor Pho/dYY1 and dSfmbt. PhoRC constitutively occupies short Polycomb response elements (PREs) of a large set of developmental regulator genes in both embryos and larvae. The majority of these PREs are co-occupied by the PcG complexes PRC1 and PRC2. Analysis of PcG ...[more]

PMID: 18993116

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