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Metabolomics,Unknown,Transcriptomics,Genomics,Proteomics

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Transcription profiling of mouse brain in male and females of three strains

ABSTRACT: Strain and sex variations are studied at the gene expression level. RNAs are extracted from two tissues (cerebral cortex and brain stem), three strains (DBA, A/J, C57BL/6) and both male and female are studied

ORGANISM(S): Mus musculus

SUBMITTER: Renee Rubio

PROVIDER: E-TIGR-104 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Transcription profiling of mouse brain in male and females of three strains

Project description:Strain and sex variations are studied at the gene expression level. RNAs are extracted from two tissues (cerebral cortex and brain stem), three strains (DBA, A/J, C57BL/6) and both male and female are studied

2013-01-30 | E-TIGR-103 | biostudies-arrayexpress

Whole transcriptome sequencing reveals dynamic RNA changes in the aging rat brain

Project description:Using RNA-seq, 9 cerebral cortex RNA samples were sequenced from 6 month (n=3, 6 individuals pooled), 12 month (n=3, 6 individuals pooled) and 28 month (n=3, 6 individuals pooled) rats. Allowing brain aging in the cerebral cortex to be assessed. Transcriptional profiling of the ageing cerebral cortex at 6, 12 and 28 months

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Gene expression in three tissues from two crab-eating macaques (Macaca fascicularis, cynomolgus monkey).

Project description:We provide RNA-Seq data for cerebral cortex, liver and kidney cortex from two untreated female crab-eating macaques.

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Transcription profiling of genetically cerebral malaria-resistant (CM-R) and cerebral malaria-susceptible (CM-S) mouse strains

Project description:Gene expression patterns were investigated in well-defined genetically cerebral malaria-resistant (CM-R) and cerebral malaria-susceptible (CM-S) mouse strains. cDNA microarrays were used to search for differentially expressed genes in mouse brain. Four mouse strains, known to differ in susceptibility to cerebral malaria upon Plasmodium berghei ANKA infection, were compared: BALB/c and DBA/2 mice are CM-R, while C57BL/6 and CBA/J mice are CM-S.

2005-06-30 | E-MEXP-370 | biostudies-arrayexpress

Transcription profiling of heart tissue among both sexes and three different strains of mouse, part 1

Project description:A comparison of heart tissue among both sexes and three different strains of mouse. Individual variations among mice is also studied.

2005-01-01 | E-TIGR-85 | biostudies-arrayexpress

Transcription profiling of heart tissue among both sexes and three different strains of mouse, part 2

Project description:A comparison of heart tissue among both sexes and three different strains of mouse. Individual variations among mice is also studied.

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An integrated analysis of gut microbiota and the brain transcriptome reveals host-gut microbiota interactions following traumatic brain injury

Project description:Objectives: The aim of this study was to reveal the transcriptomic profile of the cerebral cortex in traumatic brain injury (TBI) mice. Methods: A controlled cortical impact (CCI) device was used to establish a TBI model. The gene expression in the cerebral cortex was detected by whole-transcriptome sequencing (RNA-Seq).

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Whole transcriptome sequencing reveals dynamic RNA changes in the aging rat brain

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Diet-induced changes in gene expression of lean and obese mice in three different brain regions

Project description:By looking at the transcriptome of the hypothalamus, frontal cortex and striatum, we studied how the fine balance between the homeostatic and hedonic control of food intake can be influenced by diet

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Comparison of total and polyribosome-associated mRNA levels in male Fmr1 KO mice and male WT littermates

Project description:The Fragile X Mental Retardation Protein, FMRP, is thought to regulate the translation of a specific set of neuronal mRNAs on polyribosomes. Therefore, we prepared polyribosomes on sucrose gradients and purified mRNA specifically from these fractions, as well as the total mRNA levels, to determine whether a set of mRNAs might be changed in its % association with polyribosomes in the absence of FMRP in the KO mouse model. No significant differences were found, other than the Fmr1 transcript itself, in total mRNA levels or % polyribosome association that withstood multiple test correction, in P7 Fmr1 KO mouse cerebral cortex compared with WT littermates.. We prepared polyribosomes on sucrose gradients from 6 littermate pairs of Fmr1 KO and WT littermates (FVB background, P7 males, cerebral cortex) and purified RNA from both polyribosomal fractions and input to the gradient, reflecting total mRNA levels for comparison.

2011-07-20 | E-GEOD-26745 | biostudies-arrayexpress

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