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Metabolomics,Unknown,Transcriptomics,Genomics,Proteomics

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Comparison of lymph node negative (N0) and lymph node metastasis (N+) head and neck squamous-cell carcinomas (HNSCC)

ABSTRACT: A classifier was build on 82 training samples to differentiate between lymph node negative (N0) and lymph node metastasis (N+) head and neck squamous-cell carcinomas (HNSCC). The 102 predictor genes that resulted from this classifier where then validated against a independent validation set.

ORGANISM(S): Homo sapiens

SUBMITTER: Paul Roepman

PROVIDER: E-UMCU-11 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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An expression profile for diagnosis of lymph node metastases from primary head and neck squamous cell carcinomas.

Roepman Paul P Wessels Lodewyk F A LF Kettelarij Nienke N Kemmeren Patrick P Miles Antony J AJ Lijnzaad Philip P Tilanus Marcel G J MG Koole Ronald R Hordijk Gert-Jan GJ van der Vliet Peter C PC Reinders Marcel J T MJ Slootweg Piet J PJ Holstege Frank C P FC

Nature genetics 20050109 2

Metastasis is the process by which cancers spread to distinct sites in the body. It is the principal cause of death in individuals suffering from cancer. For some types of cancer, early detection of metastasis at lymph nodes close to the site of the primary tumor is pivotal for appropriate treatment. Because it can be difficult to detect lymph node metastases reliably, many individuals currently receive inappropriate treatment. We show here that DNA microarray gene-expression profiling can detec ...[more]

PMID: 15640797

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