Ontology highlight
ABSTRACT:
SUBMITTER: Field GC
PROVIDER: S-EPMC10005060 | biostudies-literature | 2023 Feb
REPOSITORIES: biostudies-literature
Molecules (Basel, Switzerland) 20230224 5
Arginine is a semi-essential amino acid which becomes wholly essential in many cancers commonly due to the functional loss of Argininosuccinate Synthetase 1 (ASS1). As arginine is vital for a plethora of cellular processes, its deprivation provides a rationale strategy for combatting arginine-dependent cancers. Here we have focused on pegylated arginine deiminase (ADI-PEG20, pegargiminase)-mediated arginine deprivation therapy from preclinical through to clinical investigation, from monotherapy ...[more]