Killing effect and antitoxic activity of the Leptospira interrogans toxin-antitoxin system in Escherichia coli.
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ABSTRACT:
SUBMITTER: Picardeau M
PROVIDER: S-EPMC100147 | biostudies-literature | 2001 Nov
REPOSITORIES: biostudies-literature
Publications
Killing effect and antitoxic activity of the Leptospira interrogans toxin-antitoxin system in Escherichia coli.
Picardeau M M Ren S S Saint Girons I I
Journal of bacteriology 20011101 21
We report the first evidence of a chromosome-encoded toxin-antitoxin locus in spirochetes. This locus has been found in the pathogenic spirochete Leptospira interrogans and exhibits homologies with the pem/chp loci. The L. interrogans chp locus consists of two genes: chpK (for "killer protein") and its upstream partner chpI (for "inhibitory protein"). Expression of ChpK in Escherichia coli results in the inhibition of bacterial growth. The coexpression of ChpI neutralizes ChpK toxicity. By South ...[more]
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