Ontology highlight
ABSTRACT:
SUBMITTER: Naama M
PROVIDER: S-EPMC10016318 | biostudies-literature | 2023 Mar
REPOSITORIES: biostudies-literature
Cell host & microbe 20230203 3
Colonic goblet cells are specialized epithelial cells that secrete mucus to physically separate the host and its microbiota, thus preventing bacterial invasion and inflammation. How goblet cells control the amount of mucus they secrete is unclear. We found that constitutive activation of autophagy in mice via Beclin 1 enables the production of a thicker and less penetrable mucus layer by reducing endoplasmic reticulum (ER) stress. Accordingly, genetically inhibiting Beclin 1-induced autophagy im ...[more]