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Total synthesis of bi-magnolignan.

ABSTRACT: Bi-magnolignan, isolated from the leaves of Magnolia officinalis, has shown excellent physiological activity against tumor cells. An efficient strategy for the first total synthesis of bi-magnolignan is reported. The bi-dibenzofuran skeleton was constructed via functional group interconversions of commercially available materials 1,2,4-trimethoxybenzene and 4-allylanisole. Then, the dibenzofuran skeleton was afforded by subsequent Suzuki coupling and intramolecular dehydration. The total synthesis of natural product was accomplished through FeCl₃ catalyzed oxidative coupling.

SUBMITTER: Lu SY

PROVIDER: S-EPMC10018648 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature

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Total synthesis of bi-magnolignan.

Lu Si-Yuan SY Wang Hong-Mei HM Feng Na N Ma Ai-Jun AJ

RSC advances 20230316 13

Bi-magnolignan, isolated from the leaves of <i>Magnolia</i> officinalis, has shown excellent physiological activity against tumor cells. An efficient strategy for the first total synthesis of bi-magnolignan is reported. The bi-dibenzofuran skeleton was constructed <i>via</i> functional group interconversions of commercially available materials 1,2,4-trimethoxybenzene and 4-allylanisole. Then, the dibenzofuran skeleton was afforded by subsequent Suzuki coupling and intramolecular dehydration. The ...[more]

PMID: 36936845

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