Ontology highlight
ABSTRACT:
SUBMITTER: Yuan Z
PROVIDER: S-EPMC9945064 | biostudies-literature | 2023 Feb
REPOSITORIES: biostudies-literature
Chemical science 20230130 8
Antibodies against poly(ethylene glycol) (PEG) have been found to be the culprit of side reactions and efficacy loss of a number of PEGylated drugs. Fundamental mechanisms of PEG immunogenicity and design principles for PEG alternatives still have not been fully explored. By using hydrophobic interaction chromatography (HIC) under varied salt conditions, we reveal the "hidden" hydrophobicity of those polymers which are generally considered as hydrophilic. A correlation between the hidden hydroph ...[more]