Ontology highlight
ABSTRACT:
SUBMITTER: Moghadam Farid S
PROVIDER: S-EPMC10020548 | biostudies-literature | 2023 Mar
REPOSITORIES: biostudies-literature
Moghadam Farid Sara S Noori Milad M Nazari Montazer Mohammad M Khalili Ghomi Minoo M Mollazadeh Marjan M Dastyafteh Navid N Irajie Cambyz C Zomorodian Kamiar K Mirfazli Seyedeh Sara SS Mojtabavi Somayeh S Faramarzi Mohammad Ali MA Larijani Bagher B Iraji Aida A Mahdavi Mohammad M
Scientific reports 20230316 1
In this article, different s-substituted benzimidazole-thioquinoline derivatives were designed, synthesized, and evaluated for their possible α-glucosidase inhibitory activities. The most active compound in this series, 6j (X = 4-bromobenzyl) exhibited significant potency with an IC<sub>50</sub> value of 28.0 ± 0.6 µM compared to acarbose as the positive control with an IC<sub>50</sub> value of 750.0 µM. The kinetic study showed a competitive inhibition pattern against α-glucosidase for the 6j d ...[more]