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Synthesis of ureidomuraymycidine derivatives for structure-activity relationship studies of muraymycins.

ABSTRACT: One of the key constituents of the muraymycins is the 6-membered cyclic guanidine, (2S,3S)-muraymycidine (or epi-capreomycidine). In order to diversify the structure of the oligopeptide moiety of the muraymycins for thorough structure-activity relationship studies, we have developed a highly stereoselective synthesis of ureidomuraymycidine derivatives with the lactone 4a.

SUBMITTER: Aleiwi BA

PROVIDER: S-EPMC3374721 | biostudies-literature | 2012 Apr

REPOSITORIES: biostudies-literature

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Synthesis of ureidomuraymycidine derivatives for structure-activity relationship studies of muraymycins.

Aleiwi Bilal A BA Schneider Christopher M CM Kurosu Michio M

The Journal of organic chemistry 20120406 8

One of the key constituents of the muraymycins is the 6-membered cyclic guanidine, (2S,3S)-muraymycidine (or epi-capreomycidine). In order to diversify the structure of the oligopeptide moiety of the muraymycins for thorough structure-activity relationship studies, we have developed a highly stereoselective synthesis of ureidomuraymycidine derivatives with the lactone 4a. ...[more]

PMID: 22458337

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