Dataset Information

Bone mineral density status in patients with recent-onset rheumatoid arthritis.

ABSTRACT:

Background

Osteoporosis is a sizable comorbidity complication in Rheumatoid Arthritis (RA) sufferers. In the current study, the prevalence of osteopenia and osteoporosis in active RA sufferers and the association of disease-related factors of osteoporosis and reduced bone mineral density (BMD) have been examined.

Methods

In this cross-sectional study, 300 new-onset symptoms (less than one year) RA patients without a history of glucocorticoids or DMARDs were selected. Biochemical blood measurements and BMD status were performed with dual-energy X-ray absorptiometry. According to the T-scores of the patients, they were divided into three groups: osteoporosis<-2.5, -2.5 < osteopenia <-1, and - 1 < normal. Also, the MDHAQ questionnaire, DAS-28, and FRAX criteria were calculated for all patients. Multivariate logistic regression was used to determine the associated factors of osteoporosis and osteopenia.

Results

The Prevalence of osteoporosis and osteopenia was 27% (95%CI:22-32) and 45% (95%CI:39-51), respectively. The multivariate regression analysis showed that age could play a role as an associated factor for spine/hip Osteoporosis and Osteopenia. The female gender is also a predictor of Spine osteopenia Patients with Total hip Osteoporosis were more likely to have higher DAS-28 (OR 1.86, CI 1.16-3.14) and positive CRP (OR 11.42, CI 2.65-63.26).

Conclusion

recent-onset RA patients are at risk for osteoporosis and its complications, regardless of using glucocorticoids or DMARDs. Demographic factors (e.g. age and female gender), patients' MDHAQ scores, and disease-related factors(e.g., DAS-28, positive CRP were associated with reduced BMD levels. Therefore, it is recommended that clinicians investigate early BMD measurements to have a reasonable judgment for further interventions.

Supplementary information

The online version contains supplementary material available at 10.1007/s40200-023-01200-w.

SUBMITTER: Ketabforoush AHME

PROVIDER: S-EPMC10023217 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature

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Bone mineral density status in patients with recent-onset rheumatoid arthritis.

Ketabforoush Arsh Haj Mohamad Ebrahim AHME Aleahmad Mehdi M Qorbani Mostafa M Mehrpoor Golbarg G Afrashteh Sima S Mardi Shayan S Dolatshahi Elahe E

Journal of diabetes and metabolic disorders 20230317 1

<h4>Background</h4>Osteoporosis is a sizable comorbidity complication in Rheumatoid Arthritis (RA) sufferers. In the current study, the prevalence of osteopenia and osteoporosis in active RA sufferers and the association of disease-related factors of osteoporosis and reduced bone mineral density (BMD) have been examined.<h4>Methods</h4>In this cross-sectional study, 300 new-onset symptoms (less than one year) RA patients without a history of glucocorticoids or DMARDs were selected. Biochemical b ...[more]

PMID: 37250372

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Dataset Information

Bone mineral density status in patients with recent-onset rheumatoid arthritis.

Background

Methods

Results

Conclusion

Supplementary information

Publications

Bone mineral density status in patients with recent-onset rheumatoid arthritis.

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