Dataset Information
Time-averaged disease activity of rheumatoid arthritis associated with long-term bone mineral density changes.
Ontology highlight
ABSTRACT: Background
Rheumatoid arthritis (RA) is associated with poor bone mineral density (BMD). We designed the current study owing to the lack of long-term prospective studies regarding whether a high disease activity leads to increased bone loss.Methods
We have continually enrolled patients with RA. According to the average disease activity score in 28 joints based on the erythrocyte sedimentation rate (DAS28-ESR) during follow-up, the patients were classified into remission, low disease activity, and moderate or high disease activity groups. Patients were examined with dual-energy X-ray absorptiometry at baseline and after 3?years of follow-up. BMD changes were compared among the groups.Results
We have studied 477 patients. Overall BMD was significantly reduced from baseline to the 3-year follow-up (p?ConclusionFor RA patients, if remission is achieved, AOT can better improve BMD, especially in the femur. In addition, moderate or high disease activity will lead to significant bone loss; therefore, disease activity must be actively controlled.
SUBMITTER: Hsu CY
PROVIDER: S-EPMC7768880 | biostudies-literature | 2020
REPOSITORIES: biostudies-literature
Publications
Time-averaged disease activity of rheumatoid arthritis associated with long-term bone mineral density changes.
Therapeutic advances in chronic disease 20201223
<h4>Background</h4>Rheumatoid arthritis (RA) is associated with poor bone mineral density (BMD). We designed the current study owing to the lack of long-term prospective studies regarding whether a high disease activity leads to increased bone loss.<h4>Methods</h4>We have continually enrolled patients with RA. According to the average disease activity score in 28 joints based on the erythrocyte sedimentation rate (DAS28-ESR) during follow-up, the patients were classified into remission, low dise ...[more]