Ontology highlight
ABSTRACT:
SUBMITTER: Kupke T
PROVIDER: S-EPMC10024687 | biostudies-literature | 2023 Mar
REPOSITORIES: biostudies-literature
Kupke Thomas T Götz Rabea M RM Richter Florian M FM Beck Rainer R Lolicato Fabio F Nickel Walter W Hopf Carsten C Brügger Britta B
Communications biology 20230318 1
Regulated intramembrane proteolysis (RIP) describes the protease-dependent cleavage of transmembrane proteins within the hydrophobic core of cellular membranes. Intramembrane-cleaving proteases (I-CliPs) that catalyze these reactions are found in all kingdoms of life and are involved in a wide range of cellular processes, including signaling and protein homeostasis. I-CLiPs are multispanning membrane proteins and represent challenging targets in structural and enzyme biology. Here we introduce i ...[more]