A structural metagenomics pipeline for examining the gut microbiome.
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ABSTRACT:
SUBMITTER: Walker ME
PROVIDER: S-EPMC10039758 | biostudies-literature | 2022 Aug
REPOSITORIES: biostudies-literature
Publications
A structural metagenomics pipeline for examining the gut microbiome.
Walker Morgan E ME Simpson Joshua B JB Redinbo Matthew R MR
Current opinion in structural biology 20220713
Metagenomic sequencing data provide a rich resource from which to expand our understanding of differential protein functions involved in human health. Here, we outline a pipeline that combines microbial whole genome sequencing with protein structure data to yield a structural metagenomics-informed atlas of microbial enzyme families of interest. Visualizing metagenomics data through a structural lens facilitates downstream studies including targeted inhibition and probe-based proteomics to define ...[more]
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