Adaptive and innate immune pathogenesis of bullous pemphigoid: A review.
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ABSTRACT:
SUBMITTER: Yan T
PROVIDER: S-EPMC10041874 | biostudies-literature | 2023
REPOSITORIES: biostudies-literature
Publications
Adaptive and innate immune pathogenesis of bullous pemphigoid: A review.
Yan Tianmeng T Zhang Zhenying Z
Frontiers in immunology 20230310
Bullous pemphigoid (BP) is an autoimmune blistering disease that primarily affects elderly individuals. The presentation of BP is heterogeneous, typically manifesting as microscopic subepidermal separation with a mixed inflammatory infiltrate. The mechanism of pemphigoid development is unclear. B cells play a major role in pathogenic autoantibody production, and T cells, type II inflammatory cytokines, eosinophils, mast cells, neutrophils, and keratinocytes are also implicated in the pathogenesi ...[more]
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