Ontology highlight
ABSTRACT:
SUBMITTER: Messingham KN
PROVIDER: S-EPMC6787172 | biostudies-literature | 2019
REPOSITORIES: biostudies-literature
Messingham Kelly N KN Crowe Tyler P TP Fairley Janet A JA
Frontiers in immunology 20191004
Bullous pemphigoid (BP) is an autoimmune blistering disease characterized by autoantibodies targeting cellular adhesion molecules. While IgE autoantibodies are occasionally reported in other autoimmune blistering diseases, BP is unique in that most BP patients develop an IgE autoantibody response. It is not known why BP patients develop self-reactive IgE and the precise role of IgE in BP pathogenesis is not fully understood. However, clinical evidence suggests an association between elevated IgE ...[more]