Ontology highlight
ABSTRACT:
SUBMITTER: Xiao F
PROVIDER: S-EPMC10046817 | biostudies-literature | 2023 Feb
REPOSITORIES: biostudies-literature
Xiao Fengxia F Li Jiaheng J Lagniton Philip Naderev Panuringan PNP Kou Si Hoi SH Lei Huijun H Tam Benjamin B Wang San Ming SM
Biomolecules 20230224 3
MUTYH plays an essential role in preventing oxidation-caused DNA damage. Pathogenic germline variations in <i>MUTYH</i> damage its function, causing intestinal polyposis and colorectal cancer. Determination of the evolutionary origin of the variation is essential to understanding the etiological relationship between <i>MUTYH</i> variation and cancer development. In this study, we analyzed the origins of pathogenic germline variants in human <i>MUTYH</i>. Using a phylogenic approach, we searched ...[more]