Ontology highlight
ABSTRACT:
SUBMITTER: Sarchen V
PROVIDER: S-EPMC10047333 | biostudies-literature | 2023 Mar
REPOSITORIES: biostudies-literature
Särchen Vinzenz V Reindl Lisa Marie LM Wiedemann Sara S Shanmugalingam Senthan S Bukur Thomas T Becker Julia J Suchan Martin M Ullrich Evelyn E Vogler Meike M
Cells 20230315 6
Although the overall survival in pediatric rhabdomyosarcoma (RMS) has increased over the last decades, the most aggressive subtype of alveolar RMS is in dire need of novel treatment strategies. RMS cells evade cell death induction and immune control by increasing the expression of inhibitors of apoptosis proteins (IAPs), which can be exploited and targeted with stimulation with Smac mimetics. Here, we used the Smac mimetic BV6 to re-sensitize RMS spheroids to cell death, which increased killing ...[more]