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Polymer-Based Additive Manufacturing for Orthotic and Prosthetic Devices: Industry Outlook in Canada.

ABSTRACT: The conventional manufacturing methods for fabricating orthotic and prosthetic (O&P) devices have been in practice for a very long time. Recently, O&P service providers have started exploring different advanced manufacturing techniques. The objective of this paper is to perform a mini review on recent progress in the use of polymer-based additive manufacturing (AM) for O&P devices and to gather insights from the O&P professionals on the current practices and technologies and on the prospect of using AM techniques in this field. In our study, first, scientific articles on AM for O&P devices were studied. Then, twenty-two (22) interviews were conducted with O&P professionals from Canada. The primary focus was on five key areas: cost, material, design and fabrication efficiency, structural strength, functionality, and patient satisfaction. The cost of manufacturing the O&P devices using AM techniques is lower as compared to the conventional methods. O&P professionals expressed their concern over the materials and structural strength of the 3D-printed prosthetic devices. Published articles report comparable functionality and patient satisfaction for both O&P devices. AM also greatly improves design and fabrication efficiency. However, due to a lack of qualification standards for 3D printed O&P devices, 3D printing is being embraced more slowly in the O&P business than in other industries.

SUBMITTER: Sakib-Uz-Zaman C

PROVIDER: S-EPMC10057521 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature

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Polymer-Based Additive Manufacturing for Orthotic and Prosthetic Devices: Industry Outlook in Canada.

Sakib-Uz-Zaman Chowdhury C Khondoker Mohammad Abu Hasan MAH

Polymers 20230317 6

The conventional manufacturing methods for fabricating orthotic and prosthetic (O&P) devices have been in practice for a very long time. Recently, O&P service providers have started exploring different advanced manufacturing techniques. The objective of this paper is to perform a mini review on recent progress in the use of polymer-based additive manufacturing (AM) for O&P devices and to gather insights from the O&P professionals on the current practices and technologies and on the prospect of u ...[more]

PMID: 36987285

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Project description:Additive manufacturing (AM), or 3D printing, is a growing industry involving a wide range of different techniques and materials. The potential toxicological effects of emissions produced in the process, involving both ultrafine particles and volatile organic compounds (VOCs), are unclear, and there are concerns regarding possible health implications among AM operators. The objective of this study was to screen the presence of respiratory health effects among people working with liquid, powdered, or filament plastic materials in AM.MethodsIn total, 18 subjects working with different additive manufacturing techniques and production of filament with polymer feedstock and 20 controls participated in the study. Study subjects filled out a questionnaire and underwent blood and urine sampling, spirometry, impulse oscillometry (IOS), exhaled NO test (FeNO), and collection of particles in exhaled air (PEx), and the exposure was assessed. Analysis of exhaled particles included lung surfactant components such as surfactant protein A (SP-A) and phosphatidylcholines. SP-A and albumin were determined using ELISA. Using reversed-phase liquid chromatography and targeted mass spectrometry, the relative abundance of 15 species of phosphatidylcholine (PC) was determined in exhaled particles. The results were evaluated by univariate and multivariate statistical analyses (principal component analysis).ResultsExposure and emission measurements in AM settings revealed a large variation in particle and VOC concentrations as well as the composition of VOCs, depending on the AM technique and feedstock. Levels of FeNO, IOS, and spirometry parameters were within clinical reference values for all AM operators. There was a difference in the relative abundance of saturated, notably dipalmitoylphosphatidylcholine (PC16:0_16:0), and unsaturated lung surfactant lipids in exhaled particles between controls and AM operators.ConclusionThere were no statistically significant differences between AM operators and controls for the different health examinations, which may be due to the low number of participants. However, the observed difference in the PC lipid profile in exhaled particles indicates a possible impact of the exposure and could be used as possible early biomarkers of adverse effects in the airways.

Dataset Information

Polymer-Based Additive Manufacturing for Orthotic and Prosthetic Devices: Industry Outlook in Canada.

Publications

Polymer-Based Additive Manufacturing for Orthotic and Prosthetic Devices: Industry Outlook in Canada.

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