Ontology highlight
ABSTRACT:
SUBMITTER: Ma J
PROVIDER: S-EPMC10066190 | biostudies-literature | 2023 Mar
REPOSITORIES: biostudies-literature
Nature communications 20230331 1
53BP1 promotes nonhomologous end joining (NHEJ) over homologous recombination (HR) repair by mediating inactivation of DNA end resection. Ubiquitination plays an important role in regulating dissociation of 53BP1 from DNA double-strand breaks (DSBs). However, how this process is regulated remains poorly understood. Here, we demonstrate that TRABID deubiquitinase binds to 53BP1 at endogenous level and regulates 53BP1 retention at DSB sites. TRABID deubiquitinates K29-linked polyubiquitination of ...[more]