Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

TRABID deubiquitinase overexpression enables synthetic lethality to PARP inhibitor via prolonged retention of 53BP1 at DSB sites

ABSTRACT: LSD1 and MBD3 CUT&Tag profiling in PC-3 cells treated with or without IR

ORGANISM(S): Homo sapiens

PROVIDER: GSE222267 | GEO | 2023/02/02

REPOSITORIES: GEO

ACCESS DATA

Json Xml

Similar Datasets

53BP1: a DSB escort.

Project description: Not available

| S-EPMC6938671 | biostudies-literature

UbcH7 regulates 53BP1 stability and DSB repair.

Project description: Not available

| S-EPMC4267386 | biostudies-literature

53BP1 regulates DSB repair using Rif1 to control 5' end resection.

Project description: Not available

| S-EPMC3664841 | biostudies-literature

Genome-wide analysis of gene expression by LSD1 overexpression or inhibiting by ORY1001 with or without irradiation in MDA-MB-231 breast cancer cells

Project description:Analysis of LSD1 regulation after DNA damage at gene expression level.We supposed that LSD1 is involved in Double Strand DNA repair, alterated LSD1 expression with transfection vector or LSD1 inhibtor in MDA-MB-231, and finally found LSD1 promted DNA damage reponse after IR treatment.

2021-09-19 | GSE120193 | GEO

53BP1 and the LINC Complex Promote Microtubule-Dependent DSB Mobility and DNA Repair.

Project description: Not available

| S-EPMC4636737 | biostudies-literature

53BP1-RIF1-shieldin counteracts DSB resection through CST- and Pol?-dependent fill-in.

Project description: Not available

| S-EPMC6072559 | biostudies-literature

PARP inhibitors: Synthetic lethality in the clinic.

Project description: Not available

| S-EPMC6175050 | biostudies-literature

Orchestrated intron retention regulates normal granulocyte differentiation [RNA-Seq]

Project description:Using mRNA-seq, we determined intron retaining genes that were differentially regulated in FACS purified cells at three progressive stages of mouse granulopoiesis; CD34+Kit+Gr-1low promyelocytes, CD34-Kit-Gr-1mid myelocytes and CD34-Kit-Gr-1high granulocytes. We found that IR affects 86 genes, including those specific to granulocyte (Lyz2 and MMP8) and nuclear architecture (Lmnb1 and Lbr). IR was associated with the decrease in protein levels measured by mass spectrometry (P=0.0015, binomial test). There was a significant overlap of IR between human and mouse (P=2.85E-22, hypergeometric test), showing that IR is conserved.Inhibition of NMD in granulocytes resulted in marked accumulation of 39/86 intron retaining mRNAs (P<0.05, RUV procedure with Holm-Bonferroni correction), indicating that IR triggers NMD to downregulate mRNA and protein expression. Sequencing of polyadenylated RNA from three types of myeloid cells (promyelocytes, myelocytes and granulocytes) using Illumina GAIIx

2013-06-27 | E-GEOD-48305 | biostudies-arrayexpress

Orchestrated intron retention regulates normal granulocyte differentiation [RNA-Seq]

2013-06-27 | GSE48305 | GEO

53BP1-shieldin-dependent DSB processing in BRCA1-deficient cells requires CST-Polα-primase fill-in synthesis.

Project description: Not available

| S-EPMC8849574 | biostudies-literature