Ontology highlight
ABSTRACT:
SUBMITTER: Abu Sammour D
PROVIDER: S-EPMC10067847 | biostudies-literature | 2023 Apr
REPOSITORIES: biostudies-literature
Abu Sammour Denis D Cairns James L JL Boskamp Tobias T Marsching Christian C Kessler Tobias T Ramallo Guevara Carina C Panitz Verena V Sadik Ahmed A Cordes Jonas J Schmidt Stefan S Mohammed Shad A SA Rittel Miriam F MF Friedrich Mirco M Platten Michael M Wolf Ivo I von Deimling Andreas A Opitz Christiane A CA Wick Wolfgang W Hopf Carsten C
Nature communications 20230401 1
Mass spectrometry imaging vows to enable simultaneous spatially resolved investigation of hundreds of metabolites in tissues, but it primarily relies on traditional ion images for non-data-driven metabolite visualization and analysis. The rendering and interpretation of ion images neither considers nonlinearities in the resolving power of mass spectrometers nor does it yet evaluate the statistical significance of differential spatial metabolite abundance. Here, we outline the computational frame ...[more]