Rig1 receptor plays a critical role in cardiac reprogramming via YY1 signaling.
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ABSTRACT:
SUBMITTER: Baksh SS
PROVIDER: S-EPMC10069961 | biostudies-literature | 2023 Apr
REPOSITORIES: biostudies-literature
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Rig1 receptor plays a critical role in cardiac reprogramming via YY1 signaling.
Baksh Syeda S SS Hu Jiabiao J Pratt Richard E RE Dzau Victor J VJ Hodgkinson Conrad P CP
American journal of physiology. Cell physiology 20230227 4
We discovered that innate immunity plays an important role in the reprogramming of fibroblasts into cardiomyocytes. In this report, we define the role of a novel retinoic acid-inducible gene 1 Yin Yang 1 (Rig1:YY1) pathway. We found that fibroblast to cardiomyocyte reprogramming efficacy was enhanced by specific Rig1 activators. To understand the mechanism of action, we performed various transcriptomic, nucleosome occupancy, and epigenomic approaches. Analysis of the datasets indicated that Rig1 ...[more]
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