Ontology highlight
ABSTRACT:
SUBMITTER: Paulussen FM
PROVIDER: S-EPMC10077911 | biostudies-literature | 2023 Jan
REPOSITORIES: biostudies-literature
Paulussen Felix M FM Grossmann Tom N TN
Journal of peptide science : an official publication of the European Peptide Society 20221109 1
Protein-protein interactions (PPI) are involved in all cellular processes and many represent attractive therapeutic targets. However, the frequently rather flat and large interaction areas render the identification of small molecular PPI inhibitors very challenging. As an alternative, peptide interaction motifs derived from a PPI interface can serve as starting points for the development of inhibitors. However, certain proteins remain challenging targets when applying inhibitors with a competiti ...[more]