Ontology highlight
ABSTRACT:
SUBMITTER: Gambini L
PROVIDER: S-EPMC7577563 | biostudies-literature | 2019 Jun
REPOSITORIES: biostudies-literature
Journal of medicinal chemistry 20190529 11
We have recently reported a series of Lys-covalent agents targeting the BIR3 domain of the X-linked inhibitor of apoptosis protein (XIAP) using a benzamide-sulfonyl fluoride warhead. Using XIAP as a model system, we further investigated a variety of additional warheads that can be easily incorporated into binding peptides and analyzed their ability to form covalent adducts with lysine and other amino acids, including tyrosine, histidine, serine, and threonine, using biochemical and biophysical a ...[more]