A review on the mechanistic details of OXA enzymes of ESKAPE pathogens.
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ABSTRACT:
SUBMITTER: Avci FG
PROVIDER: S-EPMC10081068 | biostudies-literature | 2023 May
REPOSITORIES: biostudies-literature
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A review on the mechanistic details of OXA enzymes of ESKAPE pathogens.
Avci Fatma Gizem FG Tastekil Ilgaz I Jaisi Amit A Ozbek Sarica Pemra P Sariyar Akbulut Berna B
Pathogens and global health 20220626 3
The production of β-lactamases is a prevalent mechanism that poses serious pressure on the control of bacterial resistance. Furthermore, the unavoidable and alarming increase in the transmission of bacteria producing extended-spectrum β-lactamases complicates treatment alternatives with existing drugs and/or approaches. Class D β-lactamases, designated as OXA enzymes, are characterized by their activity specifically towards oxacillins. They are widely distributed among the ESKAPE bugs that are a ...[more]
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