Analysis of drug binding pockets and repurposing opportunities for twelve essential enzymes of ESKAPE pathogens.

ABSTRACT:

Background

The rapid increase in antibiotic resistance by various bacterial pathogens underlies the significance of developing new therapies and exploring different drug targets. A fraction of bacterial pathogens abbreviated as ESKAPE by the European Center for Disease Prevention and Control have been considered a major threat due to the rise in nosocomial infections. Here, we compared putative drug binding pockets of twelve essential and mostly conserved metabolic enzymes in numerous bacterial pathogens including those of the ESKAPE group and Mycobacterium tuberculosis. The comparative analysis will provide guidelines for the likelihood of transferability of the inhibitors from one species to another.

Methods

Nine bacterial species including six ESKAPE pathogens,

SUBMITTER: Naz S 

PROVIDER: S-EPMC5609521 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature