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Associations between COVID-19 and hospitalisation with respiratory and non-respiratory conditions: a record linkage study.


ABSTRACT:

Objectives

To assess associations between SARS-CoV-2 infection and the incidence of hospitalisation with selected respiratory and non-respiratory conditions in a largely SARS-CoV-2 vaccine-naïve population .

Design, setting, participants

Self-control case series; analysis of population-wide surveillance and administrative data for all laboratory-confirmed COVID-19 cases notified to the Victorian Department of Health (onset, 23 January 2020 - 31 May 2021; ie, prior to widespread vaccination rollout) and linked hospital admissions data (admission dates to 30 September 2021).

Main outcome measures

Hospitalisation of people with acute COVID-19; incidence rate ratios (IRRs) comparing incidence of hospitalisations with defined conditions (including cardiac, cerebrovascular, venous thrombo-embolic, coagulative, and renal disorders) from three days before to within 89 days of onset of COVID-19 with incidence during baseline period (60-365 days prior to COVID-19 onset).

Results

A total of 20 594 COVID-19 cases were notified; 2992 people (14.5%) were hospitalised with COVID-19. The incidence of hospitalisation within 89 days of onset of COVID-19 was higher than during the baseline period for several conditions, including myocarditis and pericarditis (IRR, 14.8; 95% CI, 3.2-68.3), thrombocytopenia (IRR, 7.4; 95% CI, 4.4-12.5), pulmonary embolism (IRR, 6.4; 95% CI, 3.6-11.4), acute myocardial infarction (IRR, 3.9; 95% CI, 2.6-5.8), and cerebral infarction (IRR, 2.3; 95% CI, 1.4-3.9).

Conclusion

SARS-CoV-2 infection is associated with higher incidence of hospitalisation with several respiratory and non-respiratory conditions. Our findings reinforce the value of COVID-19 mitigation measures such as vaccination, and awareness of these associations should assist the clinical management of people with histories of SARS-CoV-2 infection.

SUBMITTER: Rowe SL 

PROVIDER: S-EPMC10100490 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature

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Publications

Associations between COVID-19 and hospitalisation with respiratory and non-respiratory conditions: a record linkage study.

Rowe Stacey L SL   Leder Karin K   Dyson Kylie K   Sundaresan Lalitha L   Wollersheim Dennis D   Lynch Brigid B   Abdullahi Ifrah I   Cowie Benjamin C BC   Stephens Nicola N   Nolan Terence M TM   Sullivan Sheena G SG   Sutton Brett B   Cheng Allen C AC  

The Medical journal of Australia 20221114 1


<h4>Objectives</h4>To assess associations between SARS-CoV-2 infection and the incidence of hospitalisation with selected respiratory and non-respiratory conditions in a largely SARS-CoV-2 vaccine-naïve population .<h4>Design, setting, participants</h4>Self-control case series; analysis of population-wide surveillance and administrative data for all laboratory-confirmed COVID-19 cases notified to the Victorian Department of Health (onset, 23 January 2020 - 31 May 2021; ie, prior to widespread va  ...[more]

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