Dataset Information

Magnetic resonance imaging reference values for cardiac morphology, function and tissue composition in adolescents.

ABSTRACT:

Background

Cardiovascular magnetic resonance (CMR) is a precise tool for the assessment of cardiac anatomy, function, and tissue composition. However, studies providing CMR reference values in adolescence are scarce. We aim to provide sex-specific CMR reference values for biventricular and atrial dimensions and function and myocardial relaxation times in this population.

Methods

Adolescents aged 15-18 years with no known cardiovascular disease underwent a non-contrast 3-T CMR scan between March 2021 and October 2021. The imaging protocol included a cine steady-state free-precession sequence for the analysis of chamber size and function, as well as T2-GraSE and native MOLLI T1-mapping for the characterization of myocardial tissue.

Findings

CMR scans were performed in 123 adolescents (mean age 16 ± 0.5 years, 52% girls). Mean left and right ventricular end-diastolic indexed volumes were higher in boys than in girls (91.7 ± 11.6 vs 78.1 ± 8.3 ml/m², p < 0.001; and 101.3 ± 14.1 vs 84.1 ± 10.5 ml/m², p < 0.001), as was the indexed left ventricular mass (48.5 ± 9.6 vs 36.6 ± 6.0 g/m², p < 0.001). Left ventricular ejection fraction showed no significant difference by sex (62.2 ± 4.1 vs 62.8 ± 4.2%, p = 0.412), whereas right ventricular ejection fraction trended slightly lower in boys (55.4 ± 4.7 vs. 56.8 ± 4.4%, p = 0.085). Indexed atrial size and function parameters did not differ significantly between sexes. Global myocardial native T1 relaxation time was lower in boys than in girls (1215 ± 23 vs 1252 ± 28 ms, p < 0.001), whereas global myocardial T2 relaxation time did not differ by sex (44.4 ± 2.0 vs 44.1 ± 2.4 ms, p = 0.384). Sex-stratified comprehensive percentile tables are provided for most relevant cardiac parameters.

Interpretation

This cross-sectional study provides overall and sex-stratified CMR reference values for cardiac dimensions and function, and myocardial tissue properties, in adolescents. This information is useful for clinical practice and may help in the differential diagnosis of cardiac diseases, such as cardiomyopathies and myocarditis, in this population.

Funding

Instituto de Salud Carlos III (PI19/01704).

SUBMITTER: Real C

PROVIDER: S-EPMC10102894 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature

ACCESS DATA

Publications

Magnetic resonance imaging reference values for cardiac morphology, function and tissue composition in adolescents.

Real Carlos C Párraga Rocío R Pizarro Gonzalo G García-Lunar Inés I González-Calvo Ernesto E Martínez-Gómez Jesús J Sánchez-González Javier J Sampedro Patricia P Sanmamed Irene I De Miguel Mercedes M De Cos-Gandoy Amaya A Bodega Patricia P Ibanez Borja B Santos-Beneit Gloria G Fuster Valentin V Fernández-Jiménez Rodrigo R

EClinicalMedicine 20230303

<h4>Background</h4>Cardiovascular magnetic resonance (CMR) is a precise tool for the assessment of cardiac anatomy, function, and tissue composition. However, studies providing CMR reference values in adolescence are scarce. We aim to provide sex-specific CMR reference values for biventricular and atrial dimensions and function and myocardial relaxation times in this population.<h4>Methods</h4>Adolescents aged 15-18 years with no known cardiovascular disease underwent a non-contrast 3-T CMR scan ...[more]

PMID: 37064511

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Dataset Information

Magnetic resonance imaging reference values for cardiac morphology, function and tissue composition in adolescents.

Background

Methods

Findings

Interpretation

Funding

Publications

Magnetic resonance imaging reference values for cardiac morphology, function and tissue composition in adolescents.

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