Quantifying the local tissue volume and composition in individual brains with magnetic resonance imaging.
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ABSTRACT:
SUBMITTER: Mezer A
PROVIDER: S-EPMC3855886 | biostudies-literature | 2013 Dec
REPOSITORIES: biostudies-literature
Publications
Quantifying the local tissue volume and composition in individual brains with magnetic resonance imaging.
Mezer Aviv A Yeatman Jason D JD Stikov Nikola N Kay Kendrick N KN Cho Nam-Joon NJ Dougherty Robert F RF Perry Michael L ML Parvizi Josef J Hua Le H le H Butts-Pauly Kim K Wandell Brian A BA
Nature medicine 20131103 12
Here, we describe a quantitative neuroimaging method to estimate the macromolecular tissue volume (MTV), a fundamental measure of brain anatomy. By making measurements over a range of field strengths and scan parameters, we tested the key assumptions and the robustness of the method. The measurements confirm that a consistent quantitative estimate of MTV can be obtained across a range of scanners. MTV estimates are sufficiently precise to enable a comparison between data obtained from an individ ...[more]
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