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Immunomodulatory Mechanisms and Therapeutic Potential of Mesenchymal Stem Cells.

ABSTRACT: Mesenchymal stem cells (MSCs) are regarded as highly promising cells for allogeneic cell therapy, owing to their multipotent nature and ability to display potent and varied functions in different diseases. The functions of MSCs, including native immunomodulation, high self-renewal characteristic, and secretory and trophic properties, can be employed to improve the immune-modulatory functions in diseases. MSCs impact most immune cells by directly contacting and/or secreting positive microenvironmental factors to influence them. Previous studies have reported that the immunomodulatory role of MSCs is basically dependent on their secretion ability from MSCs. This review discusses the immunomodulatory capabilities of MSCs and the promising strategies to successfully improve the potential utilization of MSCs in clinical research.

SUBMITTER: Yang G

PROVIDER: S-EPMC10103048 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature

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Immunomodulatory Mechanisms and Therapeutic Potential of Mesenchymal Stem Cells.

Yang Guoqiang G Fan Xuehui X Liu Yingchun Y Jie Pingping P Mazhar Maryam M Liu Yong Y Dechsupa Nathupakorn N Wang Li L

Stem cell reviews and reports 20230414 5

Mesenchymal stem cells (MSCs) are regarded as highly promising cells for allogeneic cell therapy, owing to their multipotent nature and ability to display potent and varied functions in different diseases. The functions of MSCs, including native immunomodulation, high self-renewal characteristic, and secretory and trophic properties, can be employed to improve the immune-modulatory functions in diseases. MSCs impact most immune cells by directly contacting and/or secreting positive microenvironm ...[more]

PMID: 37058201

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Immunomodulatory Mechanisms of Mesenchymal Stem Cells and Their Potential Clinical Applications.

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