Ontology highlight
ABSTRACT:
SUBMITTER: Meibom D
PROVIDER: S-EPMC10108358 | biostudies-literature | 2023 Apr
REPOSITORIES: biostudies-literature
Meibom Daniel D Meyer Jutta J von Buehler Clemens-Jeremias CJ Collins Karl D KD Maassen Stefanie S Gericke Kersten Matthias KM Hüser Jörg J Mittendorf Joachim J Ortega Hernandez Nuria N Schamberger Jens J Stampfuss Jan J Straub Alexander A Torge Afra A Witowski Norbert N Wunder Frank F
Journal of medicinal chemistry 20230318 7
After acute myocardial infarction, early reperfusion is the most effective strategy for reducing cardiac damage and improving clinical outcome. However, restoring blood flow to the ischemic myocardium can paradoxically induce injury by itself (reperfusion injury), with microvascular dysfunction being one contributing factor. α<sub>2B</sub> adrenergic receptors have been hypothesized to be involved in this process. To assess α<sub>2B</sub>-related pharmacology, we identified a novel α<sub>2B</sub ...[more]