Ontology highlight
ABSTRACT:
SUBMITTER: Moller C
PROVIDER: S-EPMC6282584 | biostudies-literature | 2018 Nov
REPOSITORIES: biostudies-literature
Möller Carsten C Bone Wilhelm W Cleve Arwed A Klar Ulrich U Rotgeri Andrea A Rottmann Antje A Schultze-Mosgau Marcus-Hillert MH Wagenfeld Andrea A Schwede Wolfgang W
ChemMedChem 20181101 21
Progesterone plays an important role in the female reproductive system. However, there is also evidence that gynecologic disorders/diseases such as uterine fibroids and endometriosis are progesterone-dependent. Steroidal and non-steroidal selective progesterone receptor modulators (SPRMs) have shown potential for the treatment of such diseases. Steroidal SPRMs, including mifepristone and ulipristal acetate, have proven effective in clinical trials. However, several steroidal SPRMs containing a d ...[more]