Ontology highlight
ABSTRACT:
SUBMITTER: Li ASM
PROVIDER: S-EPMC10108359 | biostudies-literature | 2023 Apr
REPOSITORIES: biostudies-literature
Li Alice Shi Ming ASM Kimani Serah S Wilson Brian B Noureldin Mahmoud M González-Álvarez Héctor H Mamai Ahmed A Hoffer Laurent L Guilinger John P JP Zhang Ying Y von Rechenberg Moritz M Disch Jeremy S JS Mulhern Christopher J CJ Slakman Belinda L BL Cuozzo John W JW Dong Aiping A Poda Gennady G Mohammed Mohammed M Saraon Punit P Mittal Manish M Modh Pratik P Rathod Vaibhavi V Patel Bhashant B Ackloo Suzanne S Santhakumar Vijayaratnam V Szewczyk Magdalena M MM Barsyte-Lovejoy Dalia D Arrowsmith Cheryl H CH Marcellus Richard R Guié Marie-Aude MA Keefe Anthony D AD Brown Peter J PJ Halabelian Levon L Al-Awar Rima R Vedadi Masoud M
Journal of medicinal chemistry 20230322 7
DCAF1 is a substrate receptor of two distinct E3 ligases (CRL4<sup>DCAF1</sup> and EDVP), plays a critical physiological role in protein degradation, and is considered a drug target for various cancers. Antagonists of DCAF1 could be used toward the development of therapeutics for cancers and viral treatments. We used the WDR domain of DCAF1 to screen a 114-billion-compound DNA encoded library (DEL) and identified candidate compounds using similarity search and machine learning. This led to the d ...[more]