Ontology highlight
ABSTRACT:
SUBMITTER: Donlic A
PROVIDER: S-EPMC6589350 | biostudies-literature | 2018 Oct
REPOSITORIES: biostudies-literature
Donlic Anita A Morgan Brittany S BS Xu Jason L JL Liu Anqi A Roble Carlos C Hargrove Amanda E AE
Angewandte Chemie (International ed. in English) 20180910 40
Structural studies of the 3'-end of the oncogenic long non-coding RNA metastasis-associated lung adenocarcinoma transcript 1 (MALAT1) confirmed a unique triple-helix structure. This structure enables accumulation of the transcript, and high levels of MALAT1 are found in several cancers. Here, we synthesize a small molecule library based on an RNA-binding scaffold, diphenylfuran (DPF), screen it against a variety of nucleic acid constructs, and demonstrate for the first time that the MALAT1 tripl ...[more]