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Echinocandin Resistance in Candida auris Occurs in the Murine Gastrointestinal Tract Due to FKS1 Mutations.

ABSTRACT: Candida auris is resistant to multiple antifungal agents. This study investigated its antifungal susceptibility and explored FKS1 mutations across the isolates from mice enterically colonized with wild-type C. auris and treated with echinocandin. Resistant C. auris with FKS1 mutations, including S639F, S639Y, D642Y, R1354H, or R1354Y, were isolated and found to be micafungin- and caspofungin-resistant in vivo; however, the MICs of isolates with mutation in R1354 remained below the micafungin breakpoint in vitro.

SUBMITTER: Hirayama T

PROVIDER: S-EPMC10112215 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature

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Echinocandin Resistance in Candida auris Occurs in the Murine Gastrointestinal Tract Due to FKS1 Mutations.

Hirayama Tatsuro T Miyazaki Taiga T Sumiyoshi Makoto M Ito Yuya Y Ashizawa Nobuyuki N Takeda Kazuaki K Iwanaga Naoki N Takazono Takahiro T Yamamoto Kazuko K Izumikawa Koichi K Yanagihara Katsunori K Makimura Koichi K Tsukamoto Kazuhiro K Kohno Shigeru S Mukae Hiroshi H

Antimicrobial agents and chemotherapy 20230315 4

Candida auris is resistant to multiple antifungal agents. This study investigated its antifungal susceptibility and explored FKS1 mutations across the isolates from mice enterically colonized with wild-type C. auris and treated with echinocandin. Resistant C. auris with FKS1 mutations, including S639F, S639Y, D642Y, R1354H, or R1354Y, were isolated and found to be micafungin- and caspofungin-resistant in vivo; however, the MICs of isolates with mutation in R1354 remained bel ...[more]

PMID: 36920237

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