Echinocandin failure case due to a previously unreported FKS1 mutation in Candida krusei.

ABSTRACT: Echinocandins are the preferred therapy for invasive infections due to Candida krusei. We present here a case of clinical failure involving C. krusei with a characteristic FKS1 hot spot mutation not previously reported in C. krusei that was isolated after 14 days of treatment. Anidulafungin MICs were elevated by ? 5 dilution steps above the clinical breakpoint but by only 1 step for a Candida albicans isolate harboring the corresponding mutation, suggesting a notable species-specific difference in the MIC increase conferred by this mutation.

SUBMITTER: Jensen RH 

PROVIDER: S-EPMC4068455 | biostudies-literature | 2014 Jun

REPOSITORIES: biostudies-literature