Ontology highlight
ABSTRACT:
SUBMITTER: D'Angelo F
PROVIDER: S-EPMC10112221 | biostudies-literature | 2023 Apr
REPOSITORIES: biostudies-literature
D'Angelo Francesca F Rocha Eduardo P C EPC Rendueles Olaya O
Antimicrobial agents and chemotherapy 20230313 4
The extracellular capsule is a virulence factor present in many facultative pathogens, but its role in antimicrobial resistance remains controversial. To shed light on this debate, we tested six antibiotics on four Klebsiella pneumoniae species complex strains. Noncapsulated strains exhibited increased tolerance to polymyxins, but not to other antibiotics, as measured using the MIC. Our results urge caution on the use of therapeutic agents that target the capsule and may result in selection for ...[more]