Proteomics

Dataset Information

0

Klebsiella pneumoniae protomic response to antibiotics


ABSTRACT: Bacteria can circumvent the effect of antibiotics by transitioning to a poorly understood physiological state that does not involve conventional genetic elements of resistance. Here we examine antibiotic susceptibility with a Class A β-lactamase+ invasive strain of Klebsiella pneumoniae that was isolated from a lethal outbreak within laboratory colonies of Chlorocebus aethiops sabaeus monkeys. Bacterial responses to the ribosomal synthesis inhibitors streptomycin and doxycycline resulted in distinct proteomic adjustments that facilitated decreased susceptibility to each antibiotic.

INSTRUMENT(S): Orbitrap Fusion

ORGANISM(S): Klebsiella Pneumoniae

SUBMITTER: Moo-Jin Suh  

LAB HEAD: Moojin Suh

PROVIDER: PXD009175 | Pride | 2019-03-14

REPOSITORIES: Pride

Dataset's files

Source:
Action DRS
DCBio5.mgf Mgf
DCBio5.msf Msf
DCBio5_100ng_long_1.raw Raw
DCBio5_100ng_long_2.raw Raw
DCBio6.mgf Mgf
Items per page:
1 - 5 of 36
altmetric image

Publications

Decreased Antibiotic Susceptibility Driven by Global Remodeling of the <i>Klebsiella pneumoniae</i> Proteome.

Keasey Sarah L SL   Suh Moo-Jin MJ   Das Sudipto S   Blancett Candace D CD   Zeng Xiankun X   Andresson Thorkell T   Sun Mei G MG   Ulrich Robert G RG  

Molecular & cellular proteomics : MCP 20190107 4


Bacteria can circumvent the effect of antibiotics by transitioning to a poorly understood physiological state that does not involve conventional genetic elements of resistance. Here we examine antibiotic susceptibility with a Class A β-lactamase+ invasive strain of <i>Klebsiella pneumoniae</i> that was isolated from a lethal outbreak within laboratory colonies of <i>Chlorocebus aethiops sabaeus</i> monkeys. Bacterial responses to the ribosomal synthesis inhibitors streptomycin and doxycycline re  ...[more]

Similar Datasets

2019-03-14 | PXD010244 | Pride
2023-01-04 | PXD029140 | Pride
2017-06-06 | GSE99661 | GEO
2023-01-05 | PXD034987 | Pride
2021-09-07 | GSE169651 | GEO
2023-03-05 | GSE210974 | GEO
| PRJNA32785 | ENA
2018-03-29 | GSE96706 | GEO
2011-07-18 | E-GEOD-30724 | biostudies-arrayexpress
2011-07-19 | GSE30724 | GEO