Ontology highlight
ABSTRACT:
SUBMITTER: Triglia T
PROVIDER: S-EPMC10113190 | biostudies-literature | 2023 Apr
REPOSITORIES: biostudies-literature
Triglia Tony T Scally Stephen W SW Seager Benjamin A BA Pasternak Michał M Dagley Laura F LF Cowman Alan F AF
Nature communications 20230419 1
Plasmodium falciparum causes the most severe form of malaria in humans. The protozoan parasite develops within erythrocytes to mature schizonts, that contain more than 16 merozoites, which egress and invade fresh erythrocytes. The aspartic protease plasmepsin X (PMX), processes proteins and proteases essential for merozoite egress from the schizont and invasion of the host erythrocyte, including the leading vaccine candidate PfRh5. PfRh5 is anchored to the merozoite surface through a 5-membered ...[more]