Ontology highlight
ABSTRACT:
SUBMITTER: Hayton K
PROVIDER: S-EPMC2677973 | biostudies-literature | 2008 Jul
REPOSITORIES: biostudies-literature
Cell host & microbe 20080701 1
Some human malaria Plasmodium falciparum parasites, but not others, also cause disease in Aotus monkeys. To identify the basis for this variation, we crossed two clones that differ in Aotus nancymaae virulence and mapped inherited traits of infectivity to erythrocyte invasion by linkage analysis. A major pathway of invasion was linked to polymorphisms in a putative erythrocyte binding protein, PfRH5, found in the apical region of merozoites. Polymorphisms of PfRH5 from the A. nancymaae-virulent ...[more]