Dataset Information

Determining Phase Separation Dynamics with an Automated Image Processing Algorithm.

ABSTRACT: The problems of extracting products efficiently from reaction workups are often overlooked. Issues such as emulsions and rag layer formation can cause long separation times and slow production, thus resulting in manufacturing inefficiencies. To better understand science within this area and to support process development, an image processing methodology has been developed that can automatically track the interface between liquid-liquid phases and provide a quantitative measure of the separation rate of two immiscible liquids. The algorithm is automated and has been successfully applied to 29 cases. Its robustness has been demonstrated with a variety of different liquid mixtures that exhibit a wide range of separation behavior-making such an algorithm suited to high-throughput experimentation. The information gathered from applying the algorithm shows how issues resulting from poor separations can be detected early in process development.

SUBMITTER: Daglish J

PROVIDER: S-EPMC10127267 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature

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Determining Phase Separation Dynamics with an Automated Image Processing Algorithm.

Daglish James J Blacker A John AJ de Boer Gregory G Crampton Alex A Hose David R J DRJ Parsons Anna R AR Kapur Nikil N

Organic process research & development 20230314 4

The problems of extracting products efficiently from reaction workups are often overlooked. Issues such as emulsions and rag layer formation can cause long separation times and slow production, thus resulting in manufacturing inefficiencies. To better understand science within this area and to support process development, an image processing methodology has been developed that can automatically track the interface between liquid-liquid phases and provide a quantitative measure of the separation ...[more]

PMID: 37122340

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Project description:In our digital societies, individuals massively interact through digital interfaces whose impact on collective dynamics can be important. In particular, the combination of social media filters and recommender systems can lead to the emergence of polarized and fragmented groups. In some social contexts, such segregation processes of human groups have been shown to share similarities with phase separation phenomena in physics. Here, we study the impact of information filtering on collective segregation behaviour of human groups. We report a series of experiments where groups of 22 subjects have to perform a collective segregation task that mimics the tendency of individuals to bond with other similar individuals. More precisely, the participants are each assigned a colour (red or blue) unknown to them, and have to regroup with other subjects sharing the same colour. To assist them, they are equipped with an artificial sensory device capable of detecting the majority colour in their 'environment' (defined as their k nearest neighbours, unbeknownst to them), for which we control the perception range, k = 1, 3, 5, 7, 9, 11, 13. We study the separation dynamics (emergence of unicolour groups) and the properties of the final state, and show that the value of k controls the quality of the segregation, although the subjects are totally unaware of the precise definition of the 'environment'. We also find that there is a perception range k = 7 above which the ability of the group to segregate does not improve. We introduce a model that precisely describes the random motion of a group of pedestrians in a confined space, and which faithfully reproduces and allows interpretation of the results of the segregation experiments. Finally, we discuss the strong and precise analogy between our experiment and the phase separation of two immiscible materials at very low temperature. This article is part of the theme issue 'Multi-scale analysis and modelling of collective migration in biological systems'.

Dataset Information

Determining Phase Separation Dynamics with an Automated Image Processing Algorithm.

Publications

Determining Phase Separation Dynamics with an Automated Image Processing Algorithm.

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