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Advanced Soft Robotic System for In Situ 3D Bioprinting and Endoscopic Surgery.


ABSTRACT: Three-dimensional (3D) bioprinting technology offers great potential in the treatment of tissue and organ damage. Conventional approaches generally rely on a large form factor desktop bioprinter to create in vitro 3D living constructs before introducing them into the patient's body, which poses several drawbacks such as surface mismatches, structure damage, and high contamination along with tissue injury due to transport and large open-field surgery. In situ bioprinting inside a living body is a potentially transformational solution as the body serves as an excellent bioreactor. This work introduces a multifunctional and flexible in situ 3D bioprinter (F3DB), which features a high degree of freedom soft printing head integrated into a flexible robotic arm to deliver multilayered biomaterials to internal organs/tissues. The device has a master-slave architecture and is operated by a kinematic inversion model and learning-based controllers. The 3D printing capabilities with different patterns, surfaces, and on a colon phantom are also tested with different composite hydrogels and biomaterials. The F3DB capability to perform endoscopic surgery is further demonstrated with fresh porcine tissue. The new system is expected to bridge a gap in the field of in situ bioprinting and support the future development of advanced endoscopic surgical robots.

SUBMITTER: Thai MT 

PROVIDER: S-EPMC10131836 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature

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Advanced Soft Robotic System for In Situ 3D Bioprinting and Endoscopic Surgery.

Thai Mai Thanh MT   Phan Phuoc Thien PT   Tran Hien Anh HA   Nguyen Chi Cong CC   Hoang Trung Thien TT   Davies James J   Rnjak-Kovacina Jelena J   Phan Hoang-Phuong HP   Lovell Nigel Hamilton NH   Do Thanh Nho TN  

Advanced science (Weinheim, Baden-Wurttemberg, Germany) 20230219 12


Three-dimensional (3D) bioprinting technology offers great potential in the treatment of tissue and organ damage. Conventional approaches generally rely on a large form factor desktop bioprinter to create in vitro 3D living constructs before introducing them into the patient's body, which poses several drawbacks such as surface mismatches, structure damage, and high contamination along with tissue injury due to transport and large open-field surgery. In situ bioprinting inside a living body is a  ...[more]

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