Ontology highlight
ABSTRACT:
SUBMITTER: Weinstock JS
PROVIDER: S-EPMC10132750 | biostudies-literature | 2023 Apr
REPOSITORIES: biostudies-literature
Weinstock Joshua S JS Laurie Cecelia A CA Broome Jai G JG Taylor Kent D KD Guo Xiuqing X Shuldiner Alan R AR O'Connell Jeffrey R JR Lewis Joshua P JP Boerwinkle Eric E Barnes Kathleen C KC Chami Nathalie N Kenny Eimear E EE Loos Ruth J F RJF Fornage Myriam M Redline Susan S Cade Brian E BE Gilliland Frank D FD Chen Zhanghua Z Gauderman W James WJ Kumar Rajesh R Grammer Leslie L Schleimer Robert P RP Psaty Bruce M BM Bis Joshua C JC Brody Jennifer A JA Silverman Edwin K EK Yun Jeong H JH Qiao Dandi D Weiss Scott T ST Lasky-Su Jessica J DeMeo Dawn L DL Palmer Nicholette D ND Freedman Barry I BI Bowden Donald W DW Cho Michael H MH Vasan Ramachandran S RS Johnson Andrew D AD Yanek Lisa R LR Becker Lewis C LC Kardia Sharon S He Jiang J Kaplan Robert R Heckbert Susan R SR Smith Nicholas L NL Wiggins Kerri L KL Arnett Donna K DK Irvin Marguerite R MR Tiwari Hemant H Correa Adolfo A Raffield Laura M LM Gao Yan Y de Andrade Mariza M Rotter Jerome I JI Rich Stephen S SS Manichaikul Ani W AW Konkle Barbara A BA Johnsen Jill M JM Wheeler Marsha M MM Custer Brian S BS Duggirala Ravindranath R Curran Joanne E JE Blangero John J Gui Hongsheng H Xiao Shujie S Williams L Keoki LK Meyers Deborah A DA Li Xingnan X Ortega Victor V McGarvey Stephen S Gu C Charles CC Chen Yii-Der Ida YI Lee Wen-Jane WJ Shoemaker M Benjamin MB Darbar Dawood D Roden Dan D Albert Christine C Kooperberg Charles C Desai Pinkal P Blackwell Thomas W TW Abecasis Goncalo R GR Smith Albert V AV Kang Hyun M HM Mathias Rasika R Natarajan Pradeep P Jaiswal Siddhartha S Reiner Alexander P AP Bick Alexander G AG
Science advances 20230426 17
Nononcogenic somatic mutations are thought to be uncommon and inconsequential. To test this, we analyzed 43,693 National Heart, Lung and Blood Institute Trans-Omics for Precision Medicine blood whole genomes from 37 cohorts and identified 7131 non-missense somatic mutations that are recurrently mutated in at least 50 individuals. These recurrent non-missense somatic mutations (RNMSMs) are not clearly explained by other clonal phenomena such as clonal hematopoiesis. RNMSM prevalence increased wit ...[more]