Ontology highlight
ABSTRACT:
SUBMITTER: Romanel A
PROVIDER: S-EPMC5491529 | biostudies-literature | 2017 Jun
REPOSITORIES: biostudies-literature
Romanel Alessandro A Romanel Alessandro A Garritano Sonia S Stringa Blerta B Blattner Mirjam M Dalfovo Davide D Chakravarty Dimple D Soong David D Cotter Kellie A KA Petris Gianluca G Dhingra Priyanka P Gasperini Paola P Cereseto Anna A Elemento Olivier O Sboner Andrea A Khurana Ekta E Inga Alberto A Rubin Mark A MA Demichelis Francesca F
Nature communications 20170629 1
Prostate cancer is a highly heritable molecularly and clinically heterogeneous disease. To discover germline events involved in prostate cancer predisposition, we develop a computational approach to nominate heritable facilitators of somatic genomic events in the context of the androgen receptor signaling. Here, we use a ranking score and benign prostate transcriptomes to identify a non-coding polymorphic regulatory element at 7p14.3 that associates with DNA repair and hormone-regulated transcri ...[more]