Dataset Information

The Associations of Pulse Pressure and Mean Arterial Pressure on Physical Function in Older Americans.

ABSTRACT:

Background

We sought to examine the associations of pulse pressure (PP) and mean arterial pressure (MAP) on physical function in older Americans.

Methods

Our analytic sample included 10,478 adults aged ≥65 years from the 2006-2016 Health and Retirement Study. Handgrip strength, gait speed, and standing balance were collected using relatively standard protocols. PP and MAP were calculated from blood pressure measurements.

Results

Older Americans with any abnormality in PP had 1.15 (95% confidence interval (CI): 1.05-1.25) greater odds for slowness and 1.14 (CI: 1.05-1.24) greater odds for poorer standing balance. Persons with any abnormality in MAP had 0.90 (CI: 0.82-0.98) decreased odds for weakness and 1.10 (CI: 1.01-1.20) greater odds for poorer standing balance. Those with low PP had 1.19 (CI: 1.03-1.36) greater odds for slow gait speed, while persons with low MAP had 1.50 (CI: 1.09-2.05) greater odds for weakness and 1.45 (CI: 1.03-2.04) greater odds for slowness. Older Americans with high PP had 1.13 (CI: 1.03-1.25) greater odds for slowness and 1.21 (CI: 1.10-1.32) greater odds for poorer balance, whereas those with high MAP had 0.87 (CI: 0.80-0.95) decreased odds for weakness.

Conclusions

Cardiovascular dysfunction, as observed by PP and MAP, may help to explain some of our findings.

SUBMITTER: Pleiss A

PROVIDER: S-EPMC10137340 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature

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Publications

The Associations of Pulse Pressure and Mean Arterial Pressure on Physical Function in Older Americans.

Pleiss Abigail A Jurivich Donald D Dahl Lindsey L McGrath Brenda B Kin Daniela D McGrath Ryan R

Geriatrics (Basel, Switzerland) 20230329 2

<h4>Background</h4>We sought to examine the associations of pulse pressure (PP) and mean arterial pressure (MAP) on physical function in older Americans.<h4>Methods</h4>Our analytic sample included 10,478 adults aged ≥65 years from the 2006-2016 Health and Retirement Study. Handgrip strength, gait speed, and standing balance were collected using relatively standard protocols. PP and MAP were calculated from blood pressure measurements.<h4>Results</h4>Older Americans with any abnormality in PP ha ...[more]

PMID: 37102966

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Project description:BackgroundPulse pressure (PP) and mean arterial pressure (MAP) are well-established markers of cardiovascular risk. In this study, we aimed to assess the temporal trend and associated factors of PP and MAP in Chinese children and adolescents.MethodsFrom the China Health and Nutrition Survey 1991-2015, a total of 11,123 children and adolescents aged 7-17 years were included. Stratified analyses and generalized estimating equation (GEE) were conducted to compare the trends of PP and MAP by age and sex over two decades, along with the calculation of average relative increase (ARI). Moreover, multivariable linear regression was used to estimate the associated factors of PP and MAP.ResultsDuring 1991-2015, upward trends were observed in both PP and MAP levels, with ARI of 0.30 and 0.34%, respectively. PP was higher in boys [PP1991 33.9 mmHg (95%CI, 33.40-34.33) to PP2015 35.4 mmHg (34.74-36.15)] than in girls [PP1991 33.3 mmHg (32.83-33.72) to PP2015 34.3 mmHg (33.59-34.99)]. PP was also higher in participants aged 13-17 years [PP1991 36.1 mmHg (35.63-36.62) to PP2015 38.3 mmHg (37.35-39.21)] than in those aged 7-12 years [PP1991 31.5 mmHg (31.09-31.88) to PP2015 33.7 mmHg (33.16-34.30)]. Similar results were found in MAP. Participants with high economic status, general obesity and central obesity, were more likely to have wider PP (β higheconomicstatus = 0.60, 95% CI, 0.19-1.02; β generalobesity = 1.38, 0.87-1.89; β centralobesity = 1.34, 0.70-1.97; all P-values < 0.001) and higher MAP (β higheconomicstatus = 0.82, 0.38-1.26; β generalobesity = 2.88, 2.33-3.42; β centralobesity = 3.14, 2.47-3.80; all P-values < 0.001). Body mass index (BMI) and waist circumference (WC) were positively correlated with PP (β BMI = 0.18, 0.13-0.24; β WC = 0.10, 0.08-0.12; both P-values < 0.001) and MAP (β BMI = 0.43, 0.37-0.49; β WC = 0.20, 0.18-0.22; both P-values < 0.001). In addition, rural setting and glucose level were positively associated with PP (both P < 0.05), while north region residency, uric acid, and total cholesterol were found to be positively associated with MAP (all P < 0.05).ConclusionPP and MAP levels have been increasing dramatically in Chinese children and adolescents over the last two decades. Age, sex, economic status, geographic factors, anthropometric and cardiometabolic factor were positively associated with PP and MAP in pediatric population.

Project description:ObjectivesTo examine associations between inflammation and physical function and potential mediation by white matter hyperintensities (WMHs) in African Americans (AAs) and European Americans (EAs).DesignCross-sectional analysis using linear and logistic models with generalized estimating equations to account for family clustering, reporting results as regression coefficients (β) and odds ratios (ORs) adjusted for education, alcohol, exercise, body mass index, hypertension, diabetes mellitus, heart disease, cognition, ankle-brachial index, race (site), and supported interactions.SettingGenetic Epidemiology Network of Arteriopathy-Genetics of Microangiopathic Brain Injury Study cohort.ParticipantsAA and EA sibships with two or more siblings with hypertension before age 60 (N = 1,960; 65% female, 51% AA, aged 26-91, 50% obese, 72% hypertensive).MeasurementsInflammation (C-reactive protein (CRP), interleukin-6 (IL6), soluble tumor necrosis factor receptors (sTNFRs) 1 and 2, WMH volume (cm(3) ) according to magnetic resonance imaging), walking speed (cm/s) over 25 feet, and mobility difficulty (any self-reported difficulty walking half a mile).ResultsIn separate models, inflammatory markers were associated with walking speed (sTNFR1: β = -2.74, P < .001; sTNFR2: β = -1.23, P = .03; CRP: β = -1.95, P = .001; IL6: β = -1.24, P = .03) and mobility difficulty (sTNFR1: OR = 1.36, P = .001; sTNFR2: OR = 1.25, P = .005; CRP: OR = 1.22, P = .005; IL6: OR = 1.18, P = .02); the association between WMH volume and sTNFR1 in AA (β = 0.07, P = .06) did not reach typical statistical thresholds. WMH volume was associated with walking speed in AA (β = -3.17, P = .02) but not with mobility difficulty (OR = 1.10, P = .54). Adjusting for WMH did not change associations.ConclusionIn young, middle-aged, and older adults with prevalent cardiovascular risk factors, multiple inflammatory biomarkers were associated with slower walking speed independent of microvascular disease in the brain. There was little evidence of mediation by brain WMH volume. Inflammation may contribute to physical function impairments through pathways other than brain microvascular disease, particularly in AAs.

Dataset Information

The Associations of Pulse Pressure and Mean Arterial Pressure on Physical Function in Older Americans.

Background

Methods

Results

Conclusions

Publications

The Associations of Pulse Pressure and Mean Arterial Pressure on Physical Function in Older Americans.

Similar Datasets

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