A multi-ancestry genome-wide study incorporating gene-smoking interactions identifies multiple new loci for pulse pressure and mean arterial pressure.
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ABSTRACT:
SUBMITTER: Sung YJ
PROVIDER: S-EPMC6644157 | biostudies-literature | 2019 Aug
REPOSITORIES: biostudies-literature
Publications
A multi-ancestry genome-wide study incorporating gene-smoking interactions identifies multiple new loci for pulse pressure and mean arterial pressure.
Sung Yun Ju YJ de las Fuentes Lisa L Winkler Thomas W TW Chasman Daniel I DI Bentley Amy R AR Kraja Aldi T AT Ntalla Ioanna I Warren Helen R HR Guo Xiuqing X Schwander Karen K Manning Alisa K AK Brown Michael R MR Aschard Hugues H Feitosa Mary F MF Franceschini Nora N Lu Yingchang Y Cheng Ching-Yu CY Sim Xueling X Vojinovic Dina D Marten Jonathan J Musani Solomon K SK Kilpeläinen Tuomas O TO Richard Melissa A MA Aslibekyan Stella S Bartz Traci M TM Dorajoo Rajkumar R Li Changwei C Liu Yongmei Y Rankinen Tuomo T Smith Albert Vernon AV Tajuddin Salman M SM Tayo Bamidele O BO Zhao Wei W Zhou Yanhua Y Matoba Nana N Sofer Tamar T Alver Maris M Amini Marzyeh M Boissel Mathilde M Chai Jin Fang JF Chen Xu X Divers Jasmin J Gandin Ilaria I Gao Chuan C Giulianini Franco F Goel Anuj A Harris Sarah E SE Hartwig Fernando P FP He Meian M Horimoto Andrea R V R ARVR Hsu Fang-Chi FC Jackson Anne U AU Kammerer Candace M CM Kasturiratne Anuradhani A Komulainen Pirjo P Kühnel Brigitte B Leander Karin K Lee Wen-Jane WJ Lin Keng-Hung KH Luan Jian'an J Lyytikäinen Leo-Pekka LP McKenzie Colin A CA Nelson Christopher P CP Noordam Raymond R Scott Robert A RA Sheu Wayne H H WHH Stančáková Alena A Takeuchi Fumihiko F van der Most Peter J PJ Varga Tibor V TV Waken Robert J RJ Wang Heming H Wang Yajuan Y Ware Erin B EB Weiss Stefan S Wen Wanqing W Yanek Lisa R LR Zhang Weihua W Zhao Jing Hua JH Afaq Saima S Alfred Tamuno T Amin Najaf N Arking Dan E DE Aung Tin T Barr R Graham RG Bielak Lawrence F LF Boerwinkle Eric E Bottinger Erwin P EP Braund Peter S PS Brody Jennifer A JA Broeckel Ulrich U Cade Brian B Campbell Archie A Canouil Mickaël M Chakravarti Aravinda A Cocca Massimiliano M Collins Francis S FS Connell John M JM de Mutsert Renée R de Silva H Janaka HJ Dörr Marcus M Duan Qing Q Eaton Charles B CB Ehret Georg G Evangelou Evangelos E Faul Jessica D JD Forouhi Nita G NG Franco Oscar H OH Friedlander Yechiel Y Gao He H Gigante Bruna B Gu C Charles CC Gupta Preeti P Hagenaars Saskia P SP Harris Tamara B TB He Jiang J Heikkinen Sami S Heng Chew-Kiat CK Hofman Albert A Howard Barbara V BV Hunt Steven C SC Irvin Marguerite R MR Jia Yucheng Y Katsuya Tomohiro T Kaufman Joel J Kerrison Nicola D ND Khor Chiea Chuen CC Koh Woon-Puay WP Koistinen Heikki A HA Kooperberg Charles B CB Krieger Jose E JE Kubo Michiaki M Kutalik Zoltan Z Kuusisto Johanna J Lakka Timo A TA Langefeld Carl D CD Langenberg Claudia C Launer Lenore J LJ Lee Joseph H JH Lehne Benjamin B Levy Daniel D Lewis Cora E CE Li Yize Y Lim Sing Hui SH Liu Ching-Ti CT Liu Jianjun J Liu Jingmin J Liu Yeheng Y Loh Marie M Lohman Kurt K KK Louie Tin T Mägi Reedik R Matsuda Koichi K Meitinger Thomas T Metspalu Andres A Milani Lili L Momozawa Yukihide Y Mosley Thomas H TH Nalls Mike A MA Nasri Ubaydah U O'Connell Jeff R JR Ogunniyi Adesola A Palmas Walter R WR Palmer Nicholette D ND Pankow James S JS Pedersen Nancy L NL Peters Annette A Peyser Patricia A PA Polasek Ozren O Porteous David D Raitakari Olli T OT Renström Frida F Rice Treva K TK Ridker Paul M PM Robino Antonietta A Robinson Jennifer G JG Rose Lynda M LM Rudan Igor I Sabanayagam Charumathi C Salako Babatunde L BL Sandow Kevin K Schmidt Carsten O CO Schreiner Pamela J PJ Scott William R WR Sever Peter P Sims Mario M Sitlani Colleen M CM Smith Blair H BH Smith Jennifer A JA Snieder Harold H Starr John M JM Strauch Konstantin K Tang Hua H Taylor Kent D KD Teo Yik Ying YY Tham Yih Chung YC Uitterlinden André G AG Waldenberger Melanie M Wang Lihua L Wang Ya Xing YX Wei Wen Bin WB Wilson Gregory G Wojczynski Mary K MK Xiang Yong-Bing YB Yao Jie J Yuan Jian-Min JM Zonderman Alan B AB Becker Diane M DM Boehnke Michael M Bowden Donald W DW Chambers John C JC Chen Yii-Der Ida YI Weir David R DR de Faire Ulf U Deary Ian J IJ Esko Tõnu T Farrall Martin M Forrester Terrence T Freedman Barry I BI Froguel Philippe P Gasparini Paolo P Gieger Christian C Horta Bernardo Lessa BL Hung Yi-Jen YJ Jonas Jost Bruno JB Kato Norihiro N Kooner Jaspal S JS Laakso Markku M Lehtimäki Terho T Liang Kae-Woei KW Magnusson Patrik K E PKE Oldehinkel Albertine J AJ Pereira Alexandre C AC Perls Thomas T Rauramaa Rainer R Redline Susan S Rettig Rainer R Samani Nilesh J NJ Scott James J Shu Xiao-Ou XO van der Harst Pim P Wagenknecht Lynne E LE Wareham Nicholas J NJ Watkins Hugh H Wickremasinghe Ananda R AR Wu Tangchun T Kamatani Yoichiro Y Laurie Cathy C CC Bouchard Claude C Cooper Richard S RS Evans Michele K MK Gudnason Vilmundur V Hixson James J Kardia Sharon L R SLR Kritchevsky Stephen B SB Psaty Bruce M BM van Dam Rob M RM Arnett Donna K DK Mook-Kanamori Dennis O DO Fornage Myriam M Fox Ervin R ER Hayward Caroline C van Duijn Cornelia M CM Tai E Shyong ES Wong Tien Yin TY Loos Ruth J F RJF Reiner Alex P AP Rotimi Charles N CN Bierut Laura J LJ Zhu Xiaofeng X Cupples L Adrienne LA Province Michael A MA Rotter Jerome I JI Franks Paul W PW Rice Kenneth K Elliott Paul P Caulfield Mark J MJ Gauderman W James WJ Munroe Patricia B PB Rao Dabeeru C DC Morrison Alanna C AC
Human molecular genetics 20190801 15
Elevated blood pressure (BP), a leading cause of global morbidity and mortality, is influenced by both genetic and lifestyle factors. Cigarette smoking is one such lifestyle factor. Across five ancestries, we performed a genome-wide gene-smoking interaction study of mean arterial pressure (MAP) and pulse pressure (PP) in 129 913 individuals in stage 1 and follow-up analysis in 480 178 additional individuals in stage 2. We report here 136 loci significantly associated with MAP and/or PP. Of these ...[more]