Ontology highlight
ABSTRACT:
SUBMITTER: Ajay AK
PROVIDER: S-EPMC10145398 | biostudies-literature | 2023 Apr
REPOSITORIES: biostudies-literature
Ajay Amrendra K AK Chu Philip P Patel Poojan P Deban Christa C Roychowdhury Chitran C Heda Radhika R Halawi Ahmad A Saad Anis A Younis Nour N Zhang Hao H Jiang Xiuju X Nasr Mahmoud M Hsiao Li-Li LL Lin Gang G Azzi Jamil R JR
Pharmaceutics 20230418 4
Chordomas account for approximately 1-4% of all malignant bone tumors and 20% of primary tumors of the spinal column. It is a rare disease, with an incidence estimated to be approximately 1 per 1,000,000 people. The underlying causative mechanism of chordoma is unknown, which makes it challenging to treat. Chordomas have been linked to the T-box transcription factor T (TBXT) gene located on chromosome 6. The TBXT gene encodes a protein transcription factor TBXT, or brachyury homolog. Currently, ...[more]