Ontology highlight
ABSTRACT:
SUBMITTER: Nieland TJ
PROVIDER: S-EPMC3954765 | biostudies-literature | 2014
REPOSITORIES: biostudies-literature
Nieland Thomas J F TJ Logan David J DJ Saulnier Jessica J Lam Daniel D Johnson Caroline C Root David E DE Carpenter Anne E AE Sabatini Bernardo L BL
PloS one 20140314 3
The formation of synapses, the specialized points of chemical communication between neurons, is a highly regulated developmental process fundamental to establishing normal brain circuitry. Perturbations of synapse formation and function causally contribute to human developmental and degenerative neuropsychiatric disorders, such as Alzheimer's disease, intellectual disability, and autism spectrum disorders. Many genes controlling synaptogenesis have been identified, but lack of facile experimenta ...[more]